Background and Aim: Cerebral tissue oxygenation in preterm and term neonates is of growing interest. There are no data available concerning influences of acid base status on cerebral tissue oxygenation during immediate transition after birth. Aim of the present study was therefore to investigate possible associations of acid base status and cerebral tissue oxygenation in preterm and term neonates 15 minutes after birth.
Methods: Analyses of secondary outcome parameters of prospective observational studies. Preterm and term neonates were included, in whom i) cerebral regional tissue oxygenation (crSO2) was measured during immediate transition after birth and ii) blood samples for blood gas analyses were taken between 15 to 20 minutes after birth. Arterial oxygen saturation (SpO2) and heart rate were measured by pulse oximeter on the right wrist. Cerebral fractional-tissue-oxygen-extraction (cFTOE) was calculated out of SpO2 and crSO2. Correlation analyses to investigate potential associations between crSO2/cFTOE at minute 15 after birth and acid base status (ph-value, base excess (BE), standard bicarbonate (HCO3)) were performed.
Results: 50 preterm (GA: 33±3weeks; BW: 1757±545grams) and 25 term (GA: 39±1weeks; BW: 3149±524grams) neonates were included. In preterm neonates crSO2 and cFTOE correlated significantly with ph-value (p=0.01/r=0.57 and p=0.03/r=-0.43, respectively) and BE (p=0.01/r=0.54 and p=0.02/r=-0.49, respectively). HCO3 did not correlate significantly with crSO2 or cFTOE in preterm neonates. In term neonates the acid base status parameters correlated neither with crSO2 nor with cFTOE significantly.
Conclusion: In preterm neonates immediately after birth there are associations of cerebral oxygenation and acid base status parameters whereas in term neonates these associations cannot be observed

07 - ACID BASE STATUS AND CEREBRAL OXYGENATION IN NEONATES IMMEDIATELY AFTER BIRTH