BACKGROUND: Observational studies of thrombolysis outcomes in wake-up acute ischemic stroke (AIS) patients selected based on non-contrast brain CT criteria suggested that treated patients did as well as or better than those not treated, after adjustment for baseline characteristics. We began offering thrombolytic treatment (IVTPA) to patients presenting with wake-up strokes and normal non-contrast brain CTs, who could be treated within 4.5 hours of being found.
DESIGN/METHODS: A retrospective chart review was performed in patients presenting with AIS between November 2014 and December 2017 who received IVTPA. A planned subgroup analysis compared patients with wake-up strokes and normal non-contrast brain CTs to patients with witnessed stroke treated within 4.5 hours of being found, or of witnessed onset, respectively.
RESULTS: Three hundred and six patients were treated, 279 with witnessed and 27 with wake-up strokes. Efficacy and safety were similar in both groups. Discharges home, respectively, were 143(53%) and 13(48%); facility discharges were 112(40.1%) and 11(40.7%) and in-hospital mortality was 19 (6.8%) and 3 (11%). Treatment-related symptomatic bleeds were: 5(1.8%) and 1 (3.7%), respectively.
CONCLUSIONS: The findings show that it is safe to treat patients with wake-up strokes and a normal brain CT scan with IV TPA. Demonstrating safe utilization of absence of early ischemic tissue changes on CT to expand thrombolytic treatment eligibility in patients with wake-up stroke suggests that it may be safe to extend beyond 4.5 hours the treatment eligibility window in patients with witnessed stroke onset, when the non-contrast brain CT scan is normal.

CT-GUIDED THROMBOLYTIC TREATMENT OF PATIENTS WITH WAKE-UP STROKES