Objective To investigate the relationship between the elastin gene(ELN) and the ruptured intracranial aneurysm. Methods This study enrolled spontaneous subarachnoid hemorrhagepatients who were consecutively admitted to the Neurology Departmentof Baotou Central Hospital, between December 2014 and June 2016.The control group was recruited from physical examination population in Baotou Central Hospital,which age and sex matchs with case group.Collecting venous bloodof the two group cases. Selecting the tag SNP rs2071307 of exon region of elastin gene as the research site. The polymorphism rs 2071307 of elastin gene was identified by polymerase chain reaction and genetic sequencing. Results Polymorphism distribution of elastin gene rs2071307 is existed in Inner Mongolia region population. The distribution of genotypes and alleles showed obvious racial and geographic differences. The difference of genotypes and alleles distributionof the elastin gene was not found between the case group and the control group. Conclusion The distributions of elastin gene rs2071307 genotypes and alleles showed obvious racial and geographic differences.But we found no allelic association between the elastin polymorphism haplotypeand sporadic ruptured intracranial aneurysms in Inner Mongolia region population.

The relationship between the polymorphism of elastin gene and ruptured intracranial aneurysm