Objective: We aimed to assess the diagnostic performance of 11C-Pittsburgh Compound B (PiB) positron emission tomography (PET) for underlying cerebral amyloid angiopathy (CAA) in Asian patients with spontaneous intracerebral hemorrhage (ICH).
Methods: Ninety-two spontaneous ICH patients (17 CAA, 75 non-CAA) were recruited in our study. All patients underwent PiB PET to evaluate brain amyloid retention. The amyloid burden was visually assessed and dichotomized as PiB (+) or PiB (-) (Figure). The global standardized uptake value ratio (SUVR) was calculated using the cerebellum as reference.
Results: The cerebral amyloid deposition were significantly higher in CAA than non-CAA patients (SUVR 1.40 [1.17–1.57] vs 1.07 [1.00–1.16], p<0.001). Based on visual classification, 13/18 CAA patients were PiB (+) as compared with 15/75 non-CAA patients (sensitivity=82.4% [56.6%-96.2%], specificity=80.0% [69.2%-88.4%]). Quantitative assessment using global SUVR > 1.24 as the cutoff value yielded similar findings (sensitivity=76.5% [50.1%-93.2%], specificity=85.3% [75.3%-92.4%). There was no difference in the diagnostic performance between visual ratings and quantitative assessment (p=0.29). 
Conclusions: 11C-Pittsburgh Compound B PET can be used as a diagnostic tool with high sensitivity and specificity for CAA in patients with spontaneous ICH. Visual ratings had a similar diagnostic efficacy as the quantitative method and could be readily applied in clinical and research settings.

AMYLOID IMAGING IN DIAGNOSIS OF CEREBRAL AMYLOID ANGIOPATHY RELATED INTRACEREBRAL HEMORRHAGE