To explore the amplitude of the low-frequency fluctuations(ALFF) of whole brain in leukoaraiosis patients with cognitive impairment.Here we utilized resting-state functional magnetic resonance imaging (R-fMRI) to measure the amplitude of low-frequency fluctuations (ALFF) in 28 LA patients with vascular mild cognitive impairment (LA-VaMCI), 18 LA with vascular dementia(LA-VaD) and 28 age- and sex-matched healthy controls. We showed that there were widespread differences in ALFF in many brain regions, predominantly including the right inferior temporal gyrus(ITG) and posterior cingulate cortex (PCC). Compared to controls, the LA-VaD patients had decreased ALFF values in the PCC and increased ALFF values mainly in temporal regions. The LA-VaMCI patients had increased ALFF values mainly in ITG. Finally, Close correlations were found between the ALFF values of Pcu and the memory test scores of LA-VAD patients. Our study suggests that in leukoaraiosis patients have widespread abnormalities in intrinsic brain activity, which might further affect cognitive performance.

Abnormal intrinsic brain activity patterns in leukoaraiosis patients with cognitive impairment: A resting state fMRI study