Children with SRS are characterized by intrauterine and postnatal growth retardation, feeding difficulties,  relative macrocephaly, triangular face and body and/or face asymmetry. SRS is a rare heterogeneous congenital imprinting disorder associated with loss of methylation in H19/IGF2:IG-DMR at chromosome 11p15.5 (11p15 LOM) or maternal uniparental disomy of chromosome 7 (upd(7)mat).
95 SRS patients:79 with 11p15 LOM (83,2%) – 42 boys and 37 girls and 16 with upd(7)mat (16,8%) – 10 boys and 6 girls, at age from 0,1 to 18,9 year, without growth hormone therapy, were diagnosed and followed. One patient was measured 10 times on average. Body weight, length/height were measured and BMI was calculated. The right and left side of the body were measured to diagnose body asymmetry. Growth parameters were standardized and expressed as SDS scores. 
Body weight was smaller in both boys and girls with mUPD7 (-4.17±1.28 vs. -3.86±1.83 SDS, p=0.005; -4.88±1.27 vs. -3.17±1.88 SDS, p<0,00001), as well as body length/height 
(-3.53±0.76 vs. -3.18±1.4 SDS, p=0.0003; -4.19±0.65 vs. -2,97±1,04 SDS, p<0.00001). The nutritional status assessed by BMI was lower in girls with mUPD7 (-2,29±0.96 vs. 
-1,77±1.98, p=0.004), but in group of boys in LOM11p15 (-2,69±1.89 vs. -2,44±1.21 SDS, p=0,66). The prevalence of body asymmetry was higher in LOM11p15 group (85,5% vs. 26,6 %, p<0,0001).  Body asymmetry in group of mUPD7 girls was no observed.
Conclusions 
1.	Growth parameters such as body length and weight were significantly lower in boys and girls with upd(7)mat comparing 11p15 LOM group. 
2.	Body asymmetry is more characteristic for children with 11p15 LOM .

POLISH PATIENTS WITH SILVER-RUSSELL SYNDROME (SRS): CHARACTERISTIC OF GROWTH PARAMETERS ACCORDING TO (EPI)MUTATION.