To explore for the first time an effect of gene X environment (G x E) interactions  on clinical characteristics of schizophrenia, we studied the ZNF804A polymorphism  rs1344706, a genome-wide supported risk variant of psychosis, and obstetrical complications (OC), a risk-modifying factor for psychiatric disorders, in 369 patients with schizophrenia  (203 women, mean age 29.7±10, age at disease onset  21.6±7.3). Of them, 111 patients had a history of at least one definite OC. Clinical characteristics, including age at disease onset and symptom severity assessed with the PANSS, were compared by ZNF804A genotype in the groups with-  and without OC. Patients with the risk genotype AA and OC had higher scores on the subscale of general psychopathological symptoms compared to the carriers of the CC genotype without OC (p=0.007). The results demonstrated the additive effect of ZNF804A rs1344706 and OC on symptom severity in schizophrenia.

10 - AN EFFECT OF ZNF804A AND OBSTETRICAL COMPLICATIONS ON THE SEVERITY OF SYMPTOMS IN SCHIZOPHRENIA