Background and Aims:
Sexual dysfunction figures prominently in patients with psychotic disorders, and may be related to the disease itself, psychosocial factors, somatic health and the use of psychotropic medications. However, a limited number of studies have evaluated sexual functioning in patients with psychosis without medication influence.
This study aimed to assess the current evidence about the impact of psychosis itself on sexual functioning.

Methods:
A systematic review was carried out in MEDLINE (PubMed) database, selecting articles published in English in the last 10 years that include the study of sexual functioning and psychosis, in unmedicated patients or with little use of psychotropic medications.

Results:
Data were extracted from 7 cross-sectional studies and 1 longitudinal study (Table 1). There were 681 people with first-episode psychosis, 47 people with ultra-high risk for psychosis and 264 people with schizophrenia or schizoaffective disorder. The prevalence of sexual dysfunction ranged from 37.8% to 70%, affecting all phases of sexual function. In a study, sexual dysfunction was more pronounced in first-episode psychosis than in ultra-high risk, however in another article, it was similar. The severity of psychotic symptoms was correlated with severity of sexual dysfunction. Negative symptoms were the most important.

Conclusions:
This systematic review states that both positive and negative symptoms, along with the severity, impact negatively sexual functioning, even before the onset of psychosis itself and medication.

06 - IMPACT OF PSYCHOSIS ON SEXUAL FUNCTIONING: A SYSTEMATIC REVIEW OF THE LAST 10 YEARS