Introduction: Long-term iatrogenic hyperprolactinemia due to antipsychotics (APS) is associated with physical issues such as osteoporosis, hypogonadism, dyslipidemia and increased cardiovascular risk due to an increased arteriosclerotic process. There are few studies on cardiovascular risk in the psychiatric population. Objective: To evaluate the association of Chronic Iatrogenic Hyperprolactinemia with vascular structure and function in patients treated with antipsychotics.
Methodology: Cross-sectional descriptive observational study. We recruited 27 patients (15 men, 12 women) aged 43.8 (9.6) years in treatment with antipsychotics. Vascular rigidity was evaluated by the "Cardio-Ankle-Vascular-Index" (CAVI) measuring the pulse-arm-ankle wave velocity on both sides (R-CAVI and L-CAVI) using the VASERA VS-1500® system which indicates the stiffness of the aorta, the femoral artery and the tibial artery. Results: The mean prolactin level was 35.77 (41.20) in males and 60.58 (76.19) in females. The mean values of R-CAVI and L-CAVI were equal (6.50). No relationship was found between prolactin levels and arterial age. There were significant differences between the real age and that estimated by the CAVI in both the R-CAVI (p = 0.023) and L-CAVI (p = 0.009) males and in the females (p = 0.015 and p = 0.021 respectively). The lower arterial age estimated by the CAVI, compared with the real one, does not indicate arterial aging in this group of patients. Conclusions: Due to the small size of the sample, it is necessary to continue studies on the influence of PRL levels on the risk of arteriosclerosis.

EVALUATION OF CARDIOVASCULAR RISK IN PATIENTS WITH IATROGENIC HYPERPROLACTINEMIA BY ANTIPSYCHOTICS: PRELIMINARY DATA