Background and Aims:
Plausible interplay between genetic and environmental factors is possible for high incidence of primary intracerebral haemorrhage (ICH) in eastern India. This study evaluated the dietary, conventional and genetic (Apolipoprotein E alleles) risk factors for ICH.
Methods:
First ever ICH patients over 18 years of age were included from March 2017 at Baptist Christian Hospital, Tezpur, Assam. Control subjects without ICH were recruited from the community. Dietary details were assessed by 24-hour recall method and urine spot sodium was measured. ApoE polymorphism was evaluated using RFLP polymerase chain reaction.
Results:
95 patients with ICH and 95 age matched healthy controls were enrolled. ICH cohort were more likely to have had increased consumption of alcohol [33 (34.7%) vs 9 (9.7%), p= <0.001], smoking [26 (27.4%) vs 7 (7.4%), p= <0.001], and hypertension [86 (90.5%) vs 8 (8.6%), p= <0.001] as compared to controls. Mean urinary sodium levels (mmol) were comparable ICH 104.2±57.7 vs controls 107.1±47.01,p=0.712. ICH subjects had lower calorie (777.9±289.9 vs 918.9±287.9, p =0.001) and higher salted tea intake [28 (30.1%) vs 12 (12.6%), p=0.004] in diet. ApoE polymorphisms between ICH and controls e2/e2: 2.2% vs 1.1%, e4/e4: 8.8% vs 2.3%, p=0.139) were not different. In the multivariate regression current alcohol use and smoking, low calories and consuming salted tea were the predictors for ICH.
Conclusions:
In this ongoing case control study conventional risk factors are common in ICH patients. Diet also would play a role in ICH in this region.

Funded by Indian Council of Medical Research

GENETIC, CONVENTIONAL AND DIETARY RISK FACTORS OF PRIMARY INTRACEREBRAL HEMORRHAGE FROM EASTERN INDIA