Background: Marijuana was used, according to World Drugs Report (UNODC), by 3.9% of the world population, which reveals the use of marijuana worldwide is expressive, although the literature about medical marijuana properties is inconclusive and lack of systematic reviews. 

Objectives: The aim of this study was to review the literatyre on marijuana effects on inflammatory markers.

Material and Methods: We screened all articles, published on PubMed database, that cited inflammatory markers and any information about marijuana use between 1980 to May 2019.

Results: The main findings were: i) among health volunteers and among marijuana users, cannabinoids seemed to decrease the inflammatory response; thus, decreasing the immune response, which led to a higher risk of infections; ii) among patients with Multiple Sclerosis (MS), cannabinoids seemed to have little impact on the inflammatory markers levels.
	Taking into account that auto-immune diseases, such as MS, Systematic Lupus Arythematosus, Rheumatoid arthritis, are very disabling both physically and mentally, the potential of decrease immune function by marijuana and cannabinoids extracts reveal a great importance of the cannabinoids on the inflammatory diseases treatment.

Conclusions: Although marijuana use can produce immune-inflammatory suppression in healthy people, this effect is not robust enough to change inflammatory markers’ levels in situations of highly dysfunctional inflammatory activation. Nevertheless, the impact of cannabinoids in clinical outcomes of these conditions remains to be determined.

MARIJUANA AND INFLAMMATORY MARKERS