Objectives
We aimed to highlight the diagnostic and prognostic difficulties associated with antipsychotic-related hypothermia, through a case report and literature review.
Background
Antipsychotic-related hypothermia is an under-recognized condition, consisting of a serious, unpredictable adverse drug event that commonly requires hospitalization or even intensive care unit admission. In the presence of predisposing factors such as old age, cerebrovascular accident, hypothyroidism, sepsis, benzodiazepine use, alcohol intoxication and kidney/liver failure, it may be life-threating.
Materials and methods
Case report and review of the literature.
Results
We report a case of severe hypothermia (31°C) that occurred following an increase in haloperidol dose and adjunctive chlorpromazine therapy in a female patient being treated for schizoaffective disorder. Autonomic instability was reported accompanying hypothermia such as severe hypotension and bradycardia. The problem was resolved 72 hours after discontinuation of the offending agents. Adverse drug reaction (ADR) causality and probability assessments were developed by the authors for objective temporal relationship between the event and the medications. Literature review has shown that haloperidol, chlorpromazine and olanzapine, among other antipsychotics, were found frequently in WHO databases for their potential to induce hypothermia).  
Conclusions
Considering the growing number of antipsychotic-induced hypothermia reports, we believw it is recommended that hypothermia should to be listed in the specific product characteristic (SPC) of antipsychotics to highlight an overlooked side effect of antipsychotics and alarm health care providers about it.

FIRST GENERATION ANTIPSYCHOTIC-INDUCED SEVERE HYPOTHERMIA: A CASE REPORT AND REVIEW OF THE LITERATURE