Background and Aims:
Familial Dysbetalipoproteinemia is a condition characterized by increased total cholesterol and triglycerides levels, decreased HDL levels and the presence of different isoforms of ApoE. Low prevalence (1/10000) could be associated to low detection on the population. 

Methods:
We examine the strategy of setting up the ratio VLDL/TG > 0.3 mg/dl on the routine lipid analysis that could promote the recognition of dysbetalipoproteinemia. Further clinical history review and genetic analysis of the alelic variants of ApoE (genotypes E2, E3, E4) complete the studies to confirm the diagnosis and initiate the cascade analysis for the family members.

Results
We have register 10 adults index cases (44% women / 55.5% men) with the ratio VLDL/TG >0.3mg/dl, and the genotype of ApoE analysis showed: E2/E2 22.2%, E2/E3 22.2%, E3/E3 33.3% and E3/E4 11.1% (44.4% suffered previous premature cardiovascular event). One child index case presented VLDL/TG <0.3 but with triglycerides 923 mg/dl and genotype E3/E4. The cascade analysis showed 21 adults (57.14% women / 42.85% men) with genotype distribution: E2/E2 9.52%, E2/E3 76.19%, E3/E3 14.28% and 11 individuals <18 years (45.45% boys /54.54% girls) with:  E2/E2 36.3%, E2/E3 45.45% , E3/E318.18% (33% suffered premature cardiovascular event).

Conclusions:
The implementation of this ratio on the routine lipid analysis promotes detection of dysbetalipoproteinemia, allows the cascade for the families and therefore monitoring and reducing cardiovascular events through early treatment.

06 - CASCADE SCREENING PROGRAM FOR DYSBETALIPOPROTEINEMIA THROUGH LABORATORY TEST USING THE VLDL/TG RATIO