Objective: To investigate the combined effect of Helicobacter pylori (HP) infection and elevated C-reactive protein (CRP) on the prognosis of acute ischemic stroke patients at 3 months. Methods: From June 2011 to December 2013, 1110 confirmed cases of ischemic stroke were included from 14 hospitals in China who were followed at prospective cohort study. Serum Helicobacter pylori immunoglobulin G (HP-IgG) and CRP were tested at cases admission. Outcomes were defined as death or cardiovascular events at 3 months after ischemic stroke onset. According to HP-IgG and CRP levels, all patients were divided into four groups: G1 was low-level HP-IgG/ low-level CRP, G2 was low-level HP-IgG/ CRP elevated, G3 was HP-IgG elevated/ low-level CRP and G4 was elevated HP-IgG/ elevated CRP. With G1 as a reference, logistic regression analysis was used to analyze the relationship between HP-IgG elevation with CRP elevation and the poor prognosis of ischemic stroke at 3 months respectively, and the combined effect of elevated HP-IgG with elevated CRP on poor prognosis of ischemic stroke for 3 months. Results: Within 3 months after ischemic stroke onset, a total of 38 (3.42%) patients died and 76 (6.85%) patients died or had cardiovascular events. After multifactorial adjustment, patients with elevated HP-IgG at 3 months had a 3.14-fold (95% CI: 1.30～7.57) and 2.52-fold (95% CI: 1.45～4.36) risk on death and death or cardiovascular events compared with patients with low-level HP-IgG. Patients with elevated CRP had a 3.00-fold (95% CI: 1.40～6.43) and 1.65-fold (95% CI: 0.91～2.99) risk of death and death or cardiovascular events at 3 months compared with patients with low CRP. With multifactorial adjustment, combined effects of elevated HP-IgG and elevated CRP was found that G4 patients had a 10.00-fold risk (95% CI: 2.85~35.05) of death at 3 months and 4.24-fold (95% CI: 1.83~9.85) risk of death or cardiovascular events compared with G1 patients. Conclusion: HP infection and elevated CRP have a combined effect on poor prognosis of stroke.

02 - COMBINED EFFECT OF HELICOBACTER PYLORI INFECTION AND ELEVATED C-REACTIVE PROTEIN ON 3-MONTH PROGNOSIS OF ISCHEMIC STROKE