Introduction: After cancer therapy, men with prostate cancer often face physical and psychological morbidities, and exercise could be beneficial for them. However, effect of exercise on psychosocial and sexual well-being were not consistent. The purpose of this study was to evaluate the effect of exercise interventions on physical, social, mental, and sexual function, quality of life (QOL), and depression.

Methods: Relevant papers were searched in Embase, Medline, PubMed, PsycINFO, the Chinese database Airti Library, and hand searching from 1987 to 2018. The pooled means were used Comprehensive Meta-Analysis (CMA) to calculate.

Results:  Pooling data from 10 randomized controlled trials and the results showed that exercise had positive effects on physical function (g = .91, 95% CI= .14 to 1.68), sexual activity (g = .45, 95% CI= .16 to .73), sexual function (g = .56, 95% CI= .28 to .84), and social function (g = .24, 95% CI= .01 to .48) in men with prostate cancer in this meta-analysis. But, no significant effect of exercise on QOL (g = .52, 95% CI= – .12 to 1.16), mental function (g = .45, 95% CI= − .05 to .95) and depression (g = .20, 95% CI= − .04 to .44). No deaths attributable during intervention, but one adverse event was in exercise group was design as higher exercise intensity at 50 to 75% VO2max.

Conclusions: Exercise can significantly improve social, physical, and sexual function. In future, exercise can as a support care and cobmining with psychological intervention for prostate cancer patients to enhance physical and mental well-being.

OVERCOMING LIMITATIONS OF PHYSICAL, SOCIAL, AND SEXUAL FUNCTION ON EXERCISE AMONG MEN WITH PROSTATE CANCER: A META-ANALYSIS