Purpose of the Study
Sufficient oxygen supply of heart and brain critically influences outcome after cardiac arrest (CA). Optimal results depend on the interaction of systemic and pulmonary circulation. Crucial for success are generated blood pressure and macro- and microcirculatory blood flow. Considering this, we investigated the chest compression (CC) device corpuls cpr (GS Elektromedizinische Geräte G. Stemple GmbH, Kaufering, Germany).
Materials and Methods
After approval, 52 swine underwent general anesthesia, baseline (BL) measurements and 5 minutes (min) CA. Afterwards, we commenced ventilation and mechanical CC (depth: 6cm, 100/min, continuous mode) and defibrillated after 2, 4 and 6 minutes CPR. In accordance with current guidelines, we did not use any vasopressor until third defibrillation. Monitoring data, including both mean arterial blood pressure (MAP) and mean flow of the left carotid artery (meanCF), are presented for 35 swine (40.2±4.4kg). Blood gas analyses were performed after 1, 3 and 5 minutes CPR. Global oxygen supply and demand were evaluated by oxygen extraction and arterial lactate concentration. Ventilation-perfusion mismatch was evaluated by the quotient arterial/end-tidal CO2 partial
pressure Pa/etCO2 and the arterial oxygen content CaO2. We report changes as percentage of BL.
Results
ROSC was achieved in 13/35. The oxygen extraction increased after 1 minute CPR to 243±86% of BL. 
[Please see our poster for more results in figure or table form.]
Conclusions
Using corpuls cpr in our model, we achieved adequate macrohaemodynamics. Ventilation with pure oxygen led to increased arterial oxygen levels, that may (partially) compensate ventilation-perfusion mismatch. Yet still, increasing lactate indicates anaerobic glycolysis.

4 - Global Oxygenation and Heart Lung Interaction Using “corpuls cpr” in a Real-Life Porcine Model of Cardiopulmonary Resuscitation (CPR).