Clinical studies indicate co-morbidity between depression and chronic pain. Moreover, chronic stress is associated with both conditions. Based on this, the present study investigated the relationship between social stress and inflammatory stimulus inducing depressive-like behavior and persistent hyperalgesia in mice.

THE MUTUAL INFLUENCE BETWEEN SOCIAL DEFEAT STRESS AND REPEATED INFLAMMATORY STIMULUS ON INDUCTION OF DEPRESSIVE-LIKE BEHAVIOR AND PERSISTENT HYPERALGESIA IN MICE