The aims of this study were to investigate if a multimodal rehabilitation program (MMRP) was associated with significant alterations in the plasma pattern of cytokines/chemokines, lipids, and if such changes were associated with changes in clinical aspects.
Blood samples, self-reports of pain, psychological distress and physical activity of 27 patients being referred to the Pain and Rehabilitation Centre at the University Hospital were collected before and after completing a 6-weeks of MMRP as well as 6 months and 12 months after the rehabilitation program. The concentrations of 71 cytokines/chemokines were analyzed using a customized immunoassay from Meso Scale Discovery (MSD, Rockville, MD, USA).
Significantly changes of several pro inflammatory and anti-inflammatory proteins could be detected after the MMRP compared to pre-MMRP. The plasma immune profile pre-MMRP was associated with changes in physiological distress but not with pain intensity.

THE PLASMA IMMUNE SIGNATURES AFTER AN INTERDISCIPLINARY MULTIMODAL REHABILITATION PROGRAM IN PATIENTS WITH CHRONIC PAIN