Animal studies have shown that high frequency electrical stimulation (HFS) of the sciatic nerve triggers longterm potentiation within spinal nociceptive circuits and long-lasting changes in thalamocortical networks,
manifested as a slow-wave EEG pattern (0.5-8 Hz bandwidth), recorded from electrodes covering the parietal cortex (S1). Here, we assess if HFS applied to human skin, which induces a long-lasting increase in pain sensitivity in both the area at which HFS was applied as well as the surrounding unstimulated skin, changes the ongoing EEG recorded over the left and right parietal region.

RESTING STATE EEG BEFORE AND AFTER HFS-INDUCED CENTRAL SENSITIZATION