<br/>Surfactant-stripped micelles have been formed with various near infrared dyes, including a commercially available cyanine fluroalkylphosphate salt dye (CyFaP). This enables high contrast photoacoustic imaging in the second near infrared window (NIR-II). The co-loading of Coenzyme Q10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability and results in a peak absorption wavelength in the NIR-II window close to the 1064 nm output of Nd-YAG lasers used for photoacoustic imaging. Aqueous ss-CyFaP dispersions exhibit intense NIR-II optical absorption, calculated to be greater than 500 at 1064 nm. ss-CyFaP is detected through 12 cm of chicken breast tissue with PAI. In preclinical animal models, ss-CyFaP is visualized in draining lymph nodes of rats through 3.1 cm of overlaid chicken breast tissue. Following intravenous administration, ss-CyFaP accumulates in neoplastic tissues of mice and rats bearing orthotopic mammary tumors without observation of acute toxic side effects. ss-CyFaP is imaged through whole compressed human breasts in three female volunteers at depths of 2.6 to 5.1 cm. Taken together, these data show that ss-CyFaP is an accessible contrast agent for deep tissue photoacoustic imaging in the NIR-II window. Other NIR-II contrast agents will be discussed as well, including edible contrast agents capable of rapid human translation.

Formulating Photoacoustic Agents with High Contrast at 1064 nm

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.