Ultrasound-triggered drug delivery offers a non-invasive alternative to both surgical resection and systemic drug delivery allowing higher drug concentrations at tumor sites and reduced side effects.  This talk focuses on hollow polyphenolic particles (capsules) capable of delivering anticancer therapeutics upon high-power therapeutic and low-power diagnostic ultrasound irradiation. These capsules are comprised of hydrogen-bonded multilayers of poly(N-vinylpyrrolidone) and a natural polyphenol, tannic acid deposited on sacrificial submicron templates. We will discuss capsule potential to serve as powerful contrast-enhanced imaging agents utilizing ultrasound (US), positron emission tomography (PET), and magnetic resonance imaging (MRI) modalities. We will also present capsule immunomodulatory capabilities to dissipate free radicals and influence immune responses for prolong circulation in the blood.  Due to the customizable size, composition, effective contrast, high payload concentrations, and ultrasound-guided delivery, these polyphenolic capsules represent an attractive platform for advancing the field of theranostic agents and controlled treatment in general.<br/>

Ultrasound-active theranostic microcapsules for imaging guided chemotherapy

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.