Brønsted acid/base catalysts are no longer typically understood to function as <i>either</i> an acid or base, but more often as a hybrid of two or more functions. Enantioselective catalysis has driven our understanding of the principles of bifunctional catalysis, owing to the integral role that chiral ligands play in a reaction’s mechanism. This characterization applies to chiral bis(amidine) [BAM] catalysis, an area that has played key roles in the development of nitroalkane and carboxylic acid-based reactions. Furthermore, these discoveries have been leveraged in the concise synthesis of therapeutics, facilitating hypothesis-driven research in the treatment of a broad range of disease types through key collaborations. Examples of these, with an emphasis on recent developments, will be described in this lecture.

New catalysts and strategies that enable discoveries in natural product-based therapeutic development

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.