Fundamental understandings of how bacteria interact with nanomaterials with various surface chemistry provide important insights into designing materials with desirable properties in biomedical, pharmaceutical and consumer products. As one of the primary modes of nanomaterial interaction with bacteria involves contact with the bacterial cell surface, we take a molecular approach by placing the surface chemistry of both the cells and the nanoparticles on equal footing, and examining factors that govern their interactions. This talk will focus on recent studies from my group that investigate how engineered nanoparticles with various surface functionalities result in different interactions with both Gram-positive and Gram-negative bacterial models that induce toxicity through surface binding and membrane damage. Our results show that although cationic nanoparticles often result in greater surface binding and interactions with bacterial cells, the mechanism of interactions depends on both cell surface components (such as lipopolysaccharides and teichoic acids) and the molecular conformations of the nanoparticle surface ligands.

Investigation of nanoparticle surface properties that impact interactions with model bacteria

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.