A quinoline-based fluorescence turn-on chemosensor QDTD was designed for detecting Zn2+ in aqueous solution. Detecting limit (0.27 μM) of QDTD for Zn2+ was far below World Health Organization (76.0 μM). For the practical application, sensor QDTD could be used to determine Zn2+ in real water samples and applied to the test strip. More importantly, QDTD was expertly applied for Zn2+ imaging in HeLa cells and zebrafish with good membrane-permeability. Sensing mechanism of Zn2+ ion by probe QDTD was proposed through the analytical tools such as 1H NMR titration, Job plot, ESI-MS, fluorescent and UV–vis titration, and DFT calculations, and through the synthesis and applications of a model compound AAQA.

Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.