Advanced oxidation processes (AOPs) have received tremendous attention for water treatment. Relatively few studies have been reported on peroxymonosulfate (PMS) mediated water treatment processes, despite its potential to generate two powerful oxidants, hydroxyl radical and sulfate radical. We herein report PMS leads to the rapid degradation of target H1-antihistamines, cetirizine (CET) and diphenhydramine (DPH). These compounds are problematic and commonly found in drinking water sources. Detailed product and kinetic studies were conducted using HPLC, NMR, and LC-MS/MS. Selective quenching agents were added to the reaction solutions to identify the primary reactive species responsible for the degradation. Our results indicate direct oxidation of the target compounds by PMS is the predominant transformation pathway. Influence of pH, presence of common anions (NO3–, Cl–, Br–, I–, HCO3–, CO32–, and/or phosphate buffer solution (PBS)), initial PMS concentration, and initial CET concentration was examined on both the degradation kinetics and the transformation of the H1-antihistamines. The outcome of this study contributes to the fundamental understanding of PMS mediated oxidation, which is critical to the development of PMS based water treatment technologies.

Rapid transformation of H1-antihistamines cetirizine (CET) and diphenhydramine (DPH) by peroxymonosulfate (PMS)

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.