Bioaccumulative per- and polyfluoroalkyl substances (PFAS), a large class of highly fluorinated organic chemicals, are used as surfactants in industrial and commercial applications. Their resistance to degradation and their ubiquitous presence in water, soil, animals and humans are cause for concern. PFAS chemicals such as perfluorobutane sulfonate (PFBS) and the Gen-X replacement chemicals have the potential to adversely affect cellular functions. Examinations of PFAS are conducted in the presence of a model cell membrane, specifically monolayers of 1,2-dipalmitoyl-sn-glycero-3- phosphocholine (DPPC), to better understand the alterations these chemicals may cause to the cell. This project reports surface pressure measurements obtained using a Langmuir trough to monitor changes in the fluidity and packing of a DPPC monolayer at the air-water interface upon addition of PFBS and Gen-X chemical replacements to the aqueous phase. Preliminary results suggest that while PFBS is not surface active at the neat air-water interface, it alters the surface pressure vs. area isotherm of the DPPC monolayer.

Langmuir trough studies of the interactions between per- and polyfluoroalkyl substances (PFAS) and a model cell membrane

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.