According to the WHO, approximately 38 million people across the globe are living with HIV/AIDS. Strict adherence of Highly Active Anti-Retroviral Therapy (HAART) is critical to determine treatment success and to decrease morbidity and mortality. Current methods to track adherence are unreliable (patient self-reporting, pill counting, electronic drug monitoring) or require expensive instrumentation (HPLC and/or mass spectroscopy). We are developing rapid, user-friendly and inexpensive point-of-care diagnostics to monitor adherence and efficacy. We will present our efforts to detect azidothymidine (AZT), a common HAART drug, using a fluorescence assay. We will present results that demonstrate that this “add, mix and measure” assay can detect AZT at low levels in simulated urine samples. This assay could potentially be used by clinicians and health care workers to directly monitor drug concentrations in low resource settings.

Rapid, user-friendly and inexpensive detection of azidothymidine (AZT)

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.