An alternative and effective derivatization of the active component in the contraceptive pill, ethinylestradiol (EE2), for its detection by EI-GC-MS is presented.  The method uses the environmentally benign agent, diethyl (bromodifluoromethyl) phosphonate (DBDFP), under the basic conditions at which the reaction takes place produces difluorocarbene that rapidly tags the phenol moiety in EE2.  The fluorinated derivative can be easily detected by EI-GC-MS.<br/>

Fluorination and analysis of ethinylestradiol (EE2) by EI-GC-MS and GC-MS-FPD

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.