<br/>This project is focused on developing a method that separates four NSAIDs (Ketoprofen, Naproxen, Ibuprofen, and Flurbiprofen) and three of the four pairs of enantiomers in one run.  NSAID samples were prepared with 1mg/mL of Ketoprofen, Naproxen, Ibuprofen, and Flurbiprofen and 0.5 mg/mL thiourea as a t0 marker in a sample solvent consisting of 1:1 acetonitrile and 0.1% formic acid.  Two methods were investigated, both of which employed a reversed-phase mobile phase comprised of acetonitrile and 0.2% formic acid in water.  The first method employed only a 10-cm chiral column packed with Amylose tris(3,5-dimethylphenylcarbamate) coated on silica gel, whereas the second method utilized a 5-cm C18 column coupled to a 5-cm version of the aforementioned chiral column using a zero dead volume column connector.   The results will be compared to determine the benefits and drawbacks of each approach, with an emphasis on the resolution and analysis time among the various chromatographic figures of merit evaluated. <br/>

Chiral and achiral HPLC separation of NSAIDs

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.