Proteases play a critical role in the regulation of several physiological processes and have been linked to inflammatory diseases and various cancers.  Due to the vital role of proteases to disease states, there is an immense need for highly adaptable and sensitive assays for the detection and dynamic monitoring of protease activity.  Although there are several methods to detect protease activity, fluorescence is one of the most common ways to monitor biomolecular interactions and protease activity. However, these fluorescence-based probes have a limited increment of signal change. Here we have designed a modular library of fluorogenic probes that optimized the change in signal to significantly improve the sensitivity. These reporters may have biomedical applications as diagnostic sensors and act as a versatile tool for the detection of proteases.  <br/>

Design and synthesis of sensitive fluorogenic substrates as quantitative reporters for protease activity assays

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.