Hydrogen peroxide (H2O2) is a well-known reactive oxygen species involved in a variety of biological processes, such as immune response signaling. Despite its importance, elevated H2O2 concentrations have been implicated in an array of pathologies, including Alzheimer’s and cancer. To better understand the role of H2O2 in physiology and pathology, numerous probes have been reported, many of which are unsuitable for in vivo imaging applications. Recently, reports have emerged regarding the noninvasive imaging of H2O2 using hyperpolarized 13C magnetic resonance (MR) imaging and positron emission tomography (PET). While the former approach is limited due to rapid signal decay, PET prohibits longitudinal studies owing to prolonged exposure to ionizing radiation. To address these issues, we report a modular 19F MR platform for selective detection of H2O2.

19F magnetic resonance probe for activity-based sensing of hydrogen peroxide

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.