Acetylcholinesterase (AChE) activity is largely responsible for terminating neurotransmission associated with acetylcholine. Under normal conditions, AChE hydrolyzes receptor-bound acetylcholine on the post-synaptic membrane. Alzheimer’s and other central nervous system diseases, however, are characterized by premature termination of neurotransmission owing to AChE activity. Thus, the ability to monitor changes in AChE activity may provide insight into the chemical mechanisms associated with neurodegenerative diseases. Recently, a fluorescent probe incorporating a dimethylcarbamate was shown to selectively respond to AChE activity given an increase in fluorescent response following hydrolysis of the target dimethylcarbamate. This approach, however, is limited to in vitro imaging applications given the poor penetration depth of visible light. To address this issue, we report progress towards an 19F magnetic resonance (MR) probe capable of responding to AChE activity.

Progress towards an 19F magnetic resonance probe for monitoring acetylcholinesterase activity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.