The use of engineered nanomaterials in pharmaceutical research is of critical importance in drug discovery, targeted drug delivery, and personalized medicine. Drug products containing engineered nanomaterials provide unique therapeutic opportunities.  However, because this field of research and development is rapidly changing, nanomaterial drug products present multiple pharmacological, toxicological, manufacturing, and regulatory challenges.  This talk summarizes the evolving field of nanotheranostics by exploring the crucial factors that require a multidisciplinary strategy to reach nano-enabled drug safety and efficacy.  Specifically, nanometer-sized materials have been proposed as drug-carriers and can deliver precise doses of specific drugs to targeted locations. Upon entering the blood stream, proteins readily adsorb onto and desorb from the surface of these products. This cloud of adsorbed proteins is known as the ‘protein corona’ and is postulated to critically alter either the drug product’s therapeutic (positive) or toxicological (negative) effects. In order to understand the effects related to the protein corona, detection and identification of the associated proteins, as well as the changes in the nanoparticle’s physical and chemical properties, are necessary. Data suggest control over protein corona formation is dependent on particle surface chemistry and may be predictable; the characterization-and-prediction process holds promise as an engineering technique to employ therapies. Lastly, with the safety of human health as a clear target, this talk will highlight manufacturing and analytical considerations that allow for constancy and control of novel drug products.<br/>

Characterizing nanoparticle–protein coronas: Using analytical methods to detect and identify proteins adsorbed onto gold particle surfaces

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.