The selective functionalization of ubiquitous C–H bonds can greatly streamline the construction of complex molecular architectures from easily available precursors. In particular, the development of general systems for the regio- and enantioselective transformation of C–H bonds lies at the forefront of current efforts to further advance transition-metal-catalyzed C–H functionalization. In this talk, I will discuss recent work from the Arnold lab at Caltech on using engineered cytochromes P450 for C–H amination processes. These genetically encoded enzymes are produced and function in bacteria, where they can be easily optimized by directed evolution. With this biocatalytic platform, a range of challenging C–H amination processes can be accomplished with excellent total turnover numbers in a regio- and stereocontrolled fashion.<br/>

Enantioselective C-H amination via directed evolution of cytochrome P450 enzymes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.