The interactions between a lipid bilayer and metal nanoparticles holds environmental and biomedical significance. Here, we probe the mechanism (of interaction) by following, spectroscopically, the dynamic ordering of a lipid layer from its constituent monomers in the presence of citrate stabilized gold nanoparticles (AuNPs). Individual solutions of DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine) and DMPC (1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine) in CDCl3 are titrated with 0.5 μL aliquots of pure water, D2O and respective solutions with and without AuNPs. The gradual lipid ordering is followed in separate FTIR experiments. Absorption bands for C-H, C=O and asymmetric PO2- vibrations are monitored throughout (the titration). The more pronounced shifting in band positions for C-H vibrations toward lower frequencies, consistent with transition to a more ordered crystalline orientation of C16 chains (on DPPC) on interaction with AuNPs, supports an electrostatic model of the lipid-AuNP orientation process. Our results are consistent with a recently reported electrostatic model of bilayer fluidity (in response in response to AuNP). Discussion of solvation mechanisms along with supportive hyperspectral imaging and UV/vis spectral results are presented.

Absorption IR spectroscopy tracks the effect of gold nanoparticles on the ordering of phospholipids

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.