Intracellular infections, such as Salmonella enterica and Listeria monocytogenes present a major health threat. These intracellular pathogens invade and reproduce within host cells such as macrophages, providing protection of pathogens from host defenses and antibiotic therapy. We have used biorthogonal catalysis to effectively treat intracellular Salmonella infections. Nanozymes, comprised of gold nanoparticles loaded with transition-metal catalysts, were used to activate pro-antibiotics at the site of infection. These nanozymes were functionalized to specifically target macrophage cells, creating an effective, site-specific intracellular antibiotic treatment while avoiding off-target toxicity.

Targeting of invading pathogenic bacteria using biorthogonal nanozymes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.