New concepts that combine active compounds with stable, safe carriers or membranes resulting in functional systems are on focus in a variety of domains, such as medicine, catalysis, environmental science, food science and technology. In particular, suitable amphiphilic block copolymers are ideal candidates for generation of 3D supramolecular assemblies, such as compartments, micelles, nanotubes or planar membranes. Such synthetic flexible membranes have a superior stability, and robustness compared to the lipid based membranes, and can be obtained with a variety of physical and chemical properties. Such polymeric assemblies can be combined with biomolecules by their encapsulation inside the cavity of the compartments, attachment at the surface, insertion inside the planar membranes, etc in order to provide well-defined functions, such as molecular recognition, cooperation, and catalytic activity.<br/>Here, we present distinct spaces for desired reactions based on protein-polymer assemblies that play the role of artificial organelles when internalized in cells or serve as simple mimics of cells. Biopores/channel proteins inserted into the polymer membrane selectively control the exchange of substrates and products, resulting in development of stimuli-responsive compartments, which preserve their architecture, while allowing specific in situ reactions. In a complementary approach, stimuli-responsive nanoparticles encapsulated inside giant polymer vesicles serve for recruitment of biopores and thus trigger catalytic reactions inside. This general strategy based on combination of synthetic assemblies and biomolecules supports the development of artificial organelles, proved to be functional in vitro and in vivo, and of simple processes in artificial cells.

Bio-synthetic compartments as mimics of natural organelles and cells

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.