Self-assembly of biomolecules into functional and structural entities throughout the natural world provides a fascinating blueprint to design new materials for biomedicine and biotechnology.  Inspired by these observations, in this talk, I will present our work adapting simple molecular assembly motifs, such as coiled-coil peptide scaffolds and beta-sheet peptide nanofibers, to organize proteins and carbohydrates into supramolecular architectures.  For example, I will present our work developing charge-complementary beta-sheet peptides as recombinant fusion “assembly tags” to install proteins into supramolecular hydrogels. I will also discuss our work creating nanofibers with tailored composition of carbohydrates as the basis for synthetic mimics of extracellular matrix glycoproteins. The utility of this technology is illustrated by creating nanofibers that can modulate the activity of galectins, a family of carbohydrate-binding extracellular signaling proteins.  Further, I’ll demonstrate how glycosylation of self-assembling peptides can encode their hierarchical order via emergent behavior of multivalent carbohydrates. Finally, I will describe our recent work using supramolecular peptide scaffolds to manipulate multivalent galectin-glycan interactions. For example, I’ll show how we are developing strategies to anchor biotherapeutics, such as anti-inflammatory enzymes, to specific tissue locations by engineering them to bind to abundant cell surface and extracellular matrix carbohydrates. Additionally, I’ll present examples wherein we engineer the structure and organization of galectins to understand and control their activity as extracellular signals. For example, we are developing a signaling “rheostat” by employing coiled-coil scaffolds to kinetically trap galectin-3 in assemblies with precisely defined numbers of carbohydrate-binding subunits. Together, these approaches demonstrate the enormous potential of peptide-based supramolecular scaffolds to advance the capabilities of biomaterials and biotherapeutics finding increasing use in medical and biotechnological applications.<br/>

Assembling proteins and sugars into functional materials using peptide-based supramolecular scaffolds

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.