The fate of polymer-coated Eu- and Bi-doped GdVO4 nanoparticles of cubic shape upon cellular internalization was investigated. After having been endocytosed by cells, the cubic Eu- and Bi-doped GdVO4 nanoparticle cores partly dissolved and were reshaped to rounded structures, which in control experiments could be ascribed to the acidic conditions present in endosomes/lysosomes. With ongoing time, there was a significant reduction in the amount of internalized nanoparticles per cell due to proliferation. This was of higher extent than nanoparticle exocytosis. Data of the study are compatible with the scenario that endosomal/lysosomal enzymes may partly digest the polymer shell around the nanoparticle cores, with enhanced exocytosis of the polymer fragments as compared to the nanoparticle cores.

Biodegradation of bi-labelled polymer-coated rare-earth nanoparticles in adherent cell cultures

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.