The uncontrolled growth of tumors often places their cells far away from blood vessels, thus becoming hypoxic. Hypoxia triggers the expression of many proteins, pumps, and transporters required for cellular adaptation to low PO2 and survival. Among them are the membrane-bound isozymes of carbonic anhydrase (CA), especially CA IX. CA IX is over-expressed in many hypoxic tumors and was confirmed as a valuable epitope for targeting of drug delivery systems to these malignancies [1-3]. We will present our most recent results towards targeting of two types of colloidal nanoparticles, namely gold nanoparticles and liposomes, towards hypoxic tumors via conjugation of these colloidal nanosystems with CA IX inhibitors. We will present the chemistries used for conjugation, the formulation strategies and the in vitro and in vivo results obtained with these targeted nanosystems towards doxorubicin delivery to breast and ovarian hypoxic tumors.

Carbonic anhydrase inhibitors-conjugated colloidal systems for doxorubicin delivery to hypoxic tumors

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.