Cisplatin was developed over 50 years ago and has been in the clinic for 40 years. While it is used for many different cancers, it has very negative side-effects that are typically only tolerated by patients without other options. Since this discovery, only a few potential metal-based chemotherapeutics have made it to the clinic but several non-platinum complexes, such as the anionic indazole complex [RuCl4(Ind)2]–, have shown promise. Interestingly, little is known about indazole complexes of platinum, which raises the question of whether indazole based platinum complexes could generate better chemotherapeutics.  We have synthesized several novel indazole-based complexes of platinum(II) and platinum(IV) complexes and fully characterization them spectroscopically and crystallographically.  Additionally, we have discovered both interesting chemical reactivity and appropriate interaction of these complexes with DNA models, results that suggest that these systems could be applicable for prodrug development.

Platinum indazole complexes with potential anti-cancer activity:  Synthesis, characterization, and reactivity

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.