Polyoxometalates are oxoclusters of early transition metals which have found applications in various fields from catalysis to material science or biomedicine. Among the vastly proposed biochemical applications of polyoxometalates, their interactions with peptides and proteins as well as their antibacterial activity have been gaining interest in the few years. Recently, polyoxometales (POMs) have been described as inhibitors of the Amyloid-β peptide aggregation, a peptide involved in the development of Alzheimer’s disease (AD).<br/>Metal-mediated Amyloid-β peptide aggregation and ROS production, are well known to play an important role in the development of Alzheimer’s disease. For this reason, one of the proposed therapies is based on the chelation of implicated metal ions such as Cu, Zn and Fe. Such chelators could remove the metal ions from the amyloid aggregates and recover the normal metal homeostasis. We have studied the interaction of different Keggin-structure POMs with Cu, and how, through their interaction, they can modulate the metal-mediated aggregation of amyloid- β peptides. We will also present preliminary results on POM hybrids as antimicrobial agents.

Use of polyoxometalates as bioinorganic tools: From Alzheimer's disease to biofilm disruption

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.