Antibiotic resistance is a serious and growing threat to human health. The increase in the number of resistant bacteria in recent years has been exacerbated by a decades-long lull in new antibiotic development. Accordingly, the rapid development of novel antibacterial compounds is vital to combatting antibiotic resistant bacteria. This study represents an initial investigation of the potential antibacterial properties of derivatives of denbinobin, a phytochemical and known cytotoxin produced by members of the family Orchidaceae. Precursor analogs of denbinobin were produced in house in accords with a seven-step denbinobin synthesis featuring a Claisen-Schmidt reaction. Analogs were evaluated for activity against a panel of Gram-positive and Gram-negative bacteria via standard broth microdilution assays. Screened derivatives include acid and methylester stilbeniod compounds. The results of this study serve to guide the field of novel antibiotic development towards a new natural compound of interest.<br/>

Synthesis and antibacterial evaluation of analogs of a new natural product of interest, denbinobin

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.