Catechols are found as components of natural and man-made products, including flavors, fragrances, and pesticides. Extradiol dioxygenases cleave the catecholic rings coordinated at an iron center by the vicinal oxygen atoms. Our understanding of dioxygenase mechanism is limited by the substrates available for study. To broaden our understanding of substrate space in a way that informs mechanism,  different substituents (electron donating or withdrawing) were placed at the 6-position of the catechol ring such that the interactions between these probes and the enzyme could be studied. Here we discuss progress toward the synthesis of substituted catecholic analogues, including derivatives of dopamine and 3,4-dihydroxyphenylalanine.<br/>

Synthesis of catechol derivatives as probes of dioxygenase mechanism

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.