Cobalt(III) Schiff base complexes are known to have inhibitory effects on zinc finger protein structural motifs. Targeted Co(III) Schiff base complexes have been synthesized to target Gli transcription factors known to be overactive in basal cell carcinoma (BCC) and medulloblastoma (Mb). In order to determine the effect of these drugs on cell mobility and invasiveness, scratch assays on BCC and Mb cell lines were conducted. It was determined that the Mb cell line was better suited to the scratch assay conditions used and that the hedgehog pathway controls the invasiveness of the cell line. Furthermore, synthesis of a dye arm for cobalt (III) Schiff base complex was completed through the addition of BOC-protected ethylenediamine to coumarin-3-carboxylic acid in basic conditions with the goal of monitoring drug binding to Gli protein. Product was recovered at 1.65 g (94% yield).

Cobalt III Schiff base inhibitor synthesis and biological protocol testing

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.