Flavonoids are a class of compounds that are natural components of plants, fruits, and vegetables and are primarily studied for their antioxidant, antimicrobial, and anticarcinogenic activity. Flavonols are a flavonoid that contains the 3-hydroxyflavone moiety and have the ability to release carbon monoxide (CO). Carbon monoxide-releasing molecules (CORMs) are chemical compounds designed to release controlled amounts of CO for potential therapeutic effects. Our research focuses on alternate methods for the Claisen-Schmidt condensation and subsequent Algar-Flynn-Oyamada reaction to synthesize novel flavonol-derived ligands and study the effect aryl substituents and metal-complexation has on the CO-releasing ability.

Synthesis of flavonols as ligands for metal-flavonol complexes and as CORMs for therapeutic effect

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.