Maculosin, a substance produced by the fungus <i>Alternaria alternate</i>, has phytotoxic properties and can be used as a selective herbicide targeting the invasive spotted knapweed. A synthesis plan of Maculosin derivatives has been evaluated that employs a Horner Wadsworth Emmons reaction. The key HWE precursor can be prepared in 3 steps from commercially-available materials and permits easy access to diverse Maculosin analogues, which can be assessed for herbicidal activity.

Synthesis of maculosin derivatives via Horner Wadsworth Emmons reaction

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.