In this work, we have synthesized new tert-butyloxy carbonyl protected peptide amphiphiles that were functionalized with a short sequence of laminin to form Boc-pA-Lam. The functionalized amphiphiles were then self-assembled into nanofibrils and bound to ionic liquids to form nanogels. We examined the impact of varying structures of ionic liquids (IL) and the ratio of the ionic liquid to the nanofibrils and their effects on the properties of the nanogels. The formation of nanogels was confirmed by FTIR spectroscopy and electron microscopy. Thermal, electrical and mechanical properties were studied. The nanogels were found to enhance the tensile strength and modulus of the Boc-pA-Lam nanofibers. Thermal phase changes were also seen due to strong interactions between the IL-Boc-pA-Lam. The binding interactions between the ILs and the nanofibers was probed by surface plasmon resonance. Furthermore, we examined the interactions between rat neural cortical cells with the IL-Boc-pA-Lam. Results indicated that incorporation of Boc-pA-Lam with ILs reduced cytotoxicity and the hybrid composites efficiently adhered to the cells and thus may have potential applications as scaffolds.<br/>

Exploring the interactions of ionic-liquid-peptide nanofiber gels and their potential biological applications

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.