The innate immune system recognizes pathogens by simultaneous detection of and binding to different types of ligands. Up to now, the individual role of receptors in innate immune responses has been studied extensively. In contrast, much less has been done to understand the synergistic activation of different receptor-ligand pairs. For example, the possible connection between receptor cross-talk and their spatial organization remains poorly understood. To tackle this grand question, in this study, we investigated the role of lateral positioning of membrane receptors in the innate immune regulation. We demonstrate that, by using nanolithographical patterning and bioconjugate techniques, how two types of ligands are organized on the array platforms with a series of defined spacing. The nanoarrays of patterned ligands modulate the inflammatory immune responses of macrophages via cascades of the intracellular signal transmissions.

Nanoscale organization of ligand-receptor interactions modulates macrophage activation

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.