Surface charge is essential to determine nanoparticle fate in vivo and the efficiency of nanoparticle-encapsulated drug delivery to target tissues in the body. In drug delivery, the neutral surface charge required to maximise circulation lifetimes and exposure of nanoparticles within target tissues directly conflict with the cationic surface charges required to maximise nanoparticle cellular uptake (and drug delivery) within target cells. Herein, we describe the switching of liposome surface charge, from neutral to cationic, in vivo, using light as an exclusive trigger. Visualising liposome surface charge transition in live zebrafish embryos we show liposomes, freely circulate prior to light activation, but rapidly and non-specifically adhere to all blood vessels upon light triggered activation. Structural integrity of the liposome is not compromised upon light activation leading to the successful intracellular delivery of encapsulated and membrane impermeable payloads within cells.

Photoswitching liposome surface charge to deliver membrane impermeable cargos in vivo

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.